Mercer Island residents should expect to see a lot more orange this weekend.

The annual Obliteride will again ride the Island on Saturday, Aug. 10.

About 2,500 participants will traverse routes — either by foot or on bike — spanning 25-100 miles, with two traveling around the southern, lower edge of Mercer Island.

“We invite people to make signs and come out and cheer on the riders as they pedal through and also we urge drivers to be extra cautious,” said event spokesperson Kerri Kazarba Schneider.

The fundraiser brings millions of dollars to the Fred Hutchinson Cancer Research Center, to aid in its goal of eliminating cancer and related diseases.

In its seventh year, the event has raised more than $14.6 million to support lifesaving research, according to the event website. So far in 2019, more than $1.8 million has been raised.

The Seattle-based Fred Hutchinson Cancer Research Center has interdisciplinary teams of world-renowned scientists and humanitarians, working together to fight cancer and other deadly diseases. The researchers include three Nobel laureates.

For the first time, the Amazon Spheres in Seattle will glow orange on Friday, Aug. 9, in support of the event. The company team will have about 200 people participating in this year’s event.

At about 6:30 a.m., the city estimates residents will encounter bicyclists and are asked to accommodate the event. Riders must follow all traffic laws.

Maps of the two routes winding around the Island (50-mile and 100-mile routes) are available online at www.obliteride.org.