Best Leaky Gut Supplements

Chronic inflammation of the gastrointestinal tract is a growing concern among adults. This condition is often called “leaky gut” or “leaky gut syndrome.” A leaky gut syndrome is a disorder in which undigested substances, such as gluten, toxins, and microorganisms, can enter the blood circulation. This disorder is sometimes referred to as “intestinal permeability,” which indicates that the “tight junctions” or the entryway between the intestinal wall and bloodstream have been compromised, enabling undigested particles to slip past the intestinal wall.

When these undigested particles enter the bloodstream, they induce inflammation throughout the entire body and can trigger an immunological response. A leaky gut can lead to food intolerance, arthritis, inflammatory bowel disease, skin concerns such as eczema, hypothyroidism, and more if it is not treated on time. This is complicated by the absence of a definitive medical diagnosis for leaky gut. Regarding this illness, there is still a significant amount of uncertainty in the medical community.

Most doctors will tell you that treating a leaky gut is quite complex and time-consuming, but for most people who adhere to my leaky gut diet and treatment plan, it is feasible to see benefits quickly. In addition to dietary changes, using the correct herbal supplements can significantly impact repairing a leaky gut.

In a perfect world, every supplement for leaky gut would focus on rebuilding the healthy gut lining with a mix of nutrient-rich substances. Nevertheless, this is not the case. There is a range of dietary supplements on the market today, including probiotic-based formulations. In this guide, buyers will learn which leaky gut herbal supplements on the market best suit their requirements.

But, First Things First!

What is Leaky Gut Syndrome?

When you have a leaky gut, it is crucial to understand what is happening in your body. Your digestive system cannot prevent harmful particles, toxins, or poisons from entering your bloodstream. When we have a healthy gut, the lining of our small intestine is robust and can easily absorb nutrients efficiently. The gut wall stops pathogenic microorganisms from entering the body. When intestinal permeability is compromised, even the minute openings in your intestines allow undigested food, bacteria, germs, and other poisons to enter your body.

These holes, referred to as “tight junctions,” are often small for a specific purpose. In a healthy digestive system, they are of ideal size to prevent undesirable substances from exiting the digestive tube. When these tight junctions (TJ) proteins in your gut degenerate and cannot perform their crucial function, you have a leaky gut problem. These leaks cause inflammation and alterations in the gut microbiota, the intricate balance, and the diversity of microorganisms in your digestive tract. This inflammation and microbiota alterations can result in significant health issues.

Leaky Gut Symptoms

A leaky gut can result in a variety of symptoms and diseases. Not only may this illness cause problems with your digestive system, but it can also lead to various other health problems. If you have any leaky gut symptoms, you should discuss them with your doctor, primary care physician, or healthcare expert. Some of the most common leaky gut symptoms may include:

  • Diarrhea, constipation, bloating.
  • Inflammatory bowel disease (IBD)
  • Small bacterial overgrowth (SIBO)
  • Chronic fatigue
  • Adrenal fatigue
  • Brain fog
  • Headache
  • Mood swings
  • Skin rashes, acne

And more!

How We Ranked The Best Leaky Gut Supplements

Since the leaky gut is not a recognized medical illness, there is no clinical study evaluating which supplements do and do not help treat leaky gut. Consequently, we had to modify how we rated the top leaky gut supplements by keeping in mind a variety of characteristics, including:

Science-Backed Ingredients at Clinical Dosages

Due to the lack of clinical data on the leaky gut syndrome, a transparent ingredient composition is essential. We awarded excellent ratings to goods containing probiotics and collagen since these substances have been clinically proven to enhance gut health and strengthen connective tissues and organs. We also looked for products with potent anti-inflammatory components, such as licorice root, marshmallow, and turmeric. Such powerful anti-inflammatory herbs play a crucial role as inflammation in the gut is likely the source of indigestion, diarrhea, and several other leaky gut syndrome symptoms.

Delivery System

The delivery method is how probiotics reach the body. While most of the formulas on this list are encapsulated, we preferred supplements with effective delivery mechanisms such as using a fat molecule. We ranked such supplements higher than those without such systems.

Doctor Formulated

Medical professionals created and supported some leaky gut supplements on this list. At the same time, some formulae are backed by specialists in the health and wellness business. The formulations with a real doctor on the team held a higher position in our rankings.

Honest Advertised Benefits

Ultimately, buyers want to know what advantages they will receive from this formula or what it contains. The formulas here were based on a realistic understanding of what probiotics can achieve, as opposed to the efforts of many firms to oversell their products.

Although a brand’s popularity does not necessarily affect the supplement’s ranking, the supplement’s history of transparency does. This sort of dietary supplement is prevalent, and there are several unscrupulous manufacturers on the market who may use ineffective formulae. This list is comprised solely of products from reputable firms.

Ease of Use

Personal preference is the primary determinant of usability. Some leaky gut supplements require you to take many capsules a day. Others are offered as powders that may be blended with water and consumed on the fly. There is no right or wrong manner of supplement delivery. Therefore we included a variety of supplements.

Customer Reviews

Since there are no clinical studies on leaky gut supplements, we had to sift through thousands of user reviews to identify the finest products. We analyzed the product’s rating, the number of ratings, the average rating among users, and whether or not leaky gut supplement customers finally felt better. Ultimately, the customer is the best judge of whether a product meets their needs. In analyzing our top leaky gut supplements, we heavily analyzed consumer feedback.

Moneyback Guarantee

Leaky gut is a complex topic. Some individuals may benefit from a supplement, whereas others may not observe any significant effects. Unknown factors cause intestinal permeability in a subset of persons. Others have sustained bodily injuries that are irreparable without surgery. We selected supplements with a money-back guarantee or a satisfaction guarantee.

Price & Value

Supplements for a leaky gut are typically more expensive than supplements in other categories, with some vendors charging up to $75 for a month’s supply. While it is true that you get what you pay for in the supplement sector, we believe that certain items were overpriced.

We sought the goods with the highest likelihood of delivering outcomes and the best value. Consequently, the top products included in the list provide a combination of high-quality ingredients and competitive cost, allowing you to maximize your investment while still seeing benefits.

The Top Leaky Gut Supplements in 2022

There are numerous brands of leaky gut supplements. Our staff took the time to thoroughly evaluate several of these items to compile a list of the best leaky gut supplements. After great deliberation, the following leaky gut supplements have been ranked according to the above KPIs:

  • Peak BioBoost (Peak Biome)
  • Amy Myers MD Leaky Gut Revive
  • BiOptimizers Biome Breakthrough
  • Gundry MD Bio Complete 3
  • Gundry MD Total Restore
  • Viscera-3
  • BioTrust Gut Reg
  • 1MD GutMD
  • Unify Multi-GI 5
  • ActivatedYou Morning Complete
  • Microbiome Plus Gastrointestinal

Peak BioBoost (Peak Biome)


Peak BioBoost appears to be a product that can enhance digestion and bowel motions. By adding this supplement to coffee or tea once per day, consumers may be able to dramatically improve their capacity to have regular, healthy bowel movements.

Having stool waste in your bowels for days can cause gastrointestinal problems and quickly escalate into a much larger problem than necessary. This supplement may assist you in defecating. This supplement’s mentioned sources indicate that its constituents can increase stool softness in users.

This dietary supplement is mixable and contains multiple components. This lends credibility to the numerous benefits the supplement’s producer listed on the product’s official website. Regarding the supplement’s primary ingredients, the manufacturer appears honest.

Amy Myers MD Leaky Gut Revive


Leaky Gut Revive is among the market’s most effective leaky gut supplements. It is renowned for its scientifically formulated combination of digestive health-promoting substances. Renowned functional medicine specialist Amy Myers designed Leaky Gut Revive to decrease gut inflammation and enhance gut permeability to stop leaky gut.

Leaky Gut Revive contains glutamine to aid in the restoration of the intestinal lining by stimulating protein synthesis for cell reproduction. DGL (a type of licorice) aids in the formation of a healthy intestinal barrier, while marshmallow root provides a protective coating over the intestinal lining. There are thousands of satisfied customers worldwide. The formula is supported by research and endorsed by one of the world’s most esteemed physicians. Leaky Gut Revive is an obvious choice.

BiOptimizers Biome Breakthrough


BiOptimizers Biome Breakthrough comprises good bacterial strains that aid in the development of healthy intestinal flora. In addition to the prebiotic fiber, it contains three varieties of probiotic bacteria that have been proven to treat the leaky gut syndrome. These potent bacterial strains are Lactobacillus Rhamnosus, Gasseri, and Helveticus bacteria. The company also uses inulin and isomalto-oligosaccharides as prebiotic fibers (Vitafiber). This combination of bacteria and fiber alters the intestines’ flora permanently.

This leaky gut supplement is offered in chocolate and vanilla flavors. The chocolate flavor includes beef collagen and bone broth. The vanilla flavor is consequently suitable for vegetarians due to the absence of these components. BiOptimizers is also an expert in producing supplements for healthy intestines and proper digestion. Their ingredients are subject to highly stringent regulations. BiOptimizers donates one bottle for every ten sold to a deserving recipient.

Gundry MD Bio Complete 3


GundryMD Bio Complete 3 is a potent digestive health supplement. Bio Complete 3 is a fundamental supplement containing prebiotic, probiotic, and postbiotic components. Prebiotics are intended to nourish beneficial gut microorganisms. Over 10 billion live CFUs, or colony-forming units, are delivered to the gut by probiotics (live bacteria). Post-biotics aid in preventing leaky gut by providing a protective coating on the gut lining. It may be most effective when combined with other supplements for comprehensive digestive support, but it is certainly potent enough to prevent a leaky gut.

Gundry MD Total Restore


Gundry MD Total Reserve is an all-natural leaky gut supplement to reinforce your gut lining. Magnesium, glutamine, and glucosamine promote cell reproduction in the gut and provide an additional layer of protection for the stomach lining. Other anti-inflammatory compounds, such as cinnamon, licorice, grape seed, and grapefruit, aid in reducing inflammation that causes stomach pain, bloating gas, and other digestive difficulties. Total Reserve contains components with a history of supporting digestive health. It was created by Gundry MD, a supplement industry pioneer, and is one of the most highly rated leaky gut supplements available online.



Viscera-3 identifies itself as a “post-biotic” supplement intended to boost the overall health of the digestive tract. Viscera-3 is a prebiotic and probiotic supplement designed to “detoxify” the digestive tract, reduce gut inflammation, and promote colon health. According to the official website, this nutritional supplement targets the cause of difficulties excreting and digestive disorders with natural ingredients.

The primary component of SANE Viscera-3 tablets is TRIButyrate. This chemical is administered directly to the colon to improve its function. Additional vitamins and minerals have been added to the formula, including chromium, suppressing appetite and reducing body weight. Viscera-3 is an excellent product with numerous positive qualities.

BioTrust Gut Reg


Using a proprietary substance called PepZin GI, BioTrust Gut Reg strengthens the intestine’s lining. PepZin GI is a proprietary zinc and L-carnosine compound, and nearly twenty clinical investigations support its digestive effects. In addition to PepZin, Gut Reg contains glutamine, known to reinforce digestive organ walls, and ginger. It acts as a potent immune-boosting plant.

Each of the bacterial strains in this mixture is supported by scientific evidence for its benefits. Each has already been discovered in at least one of the supplements on the list. Strains include Bifidobacterium breve, Bifidobacterium lactis, Lactobacillus acidophilus, Lactobacillus Plantarum, and Lactobacillus rhamnosus. Most individuals use this mixture to alleviate cramping, heartburn, upset stomach, and other common digestive issues. Given the formulation’s balance of different constituents, it is safe to consume with other supplements.



GutMD is ideal for eliminating leaky gut if you require a more potent, proven product. 1MD is one of the most reputable supplement brands, and their leaky gut supplement is one of the best. This supplement, known as 1MD GutMD, is designed to mend the gut lining.

GutMD utilizes three proprietary chemicals in addition to glutamine to rebuild intestinal epithelial epithelium. GutGuard, a unique licorice, protects the GI tract lining from harmful bacteria, while HMO Care4U actively reduces the number of harmful bacteria in your system. Overall, GutMD is one of the few remedies for leaky gut supported by clinically researched substances.

Unify Multi-GI 5


Unify Multi-GI 5 formula consists of probiotics, prebiotics, and a wellness blend to help the digestive system. With prebiotics, probiotics, and a “GI health” blend, Multi G1-5 utilizes a three-pronged strategy to eliminate leaky gut. This potent mixture strengthens the lining of the digestive tract, removes inflammation in the digestive tract, and improves nutritional absorption.

This recipe contains sixteen distinct substances to boost the health of the user. The price of Multi GI-5 is the only thing truly holding it back. It is somewhat more expensive than other leaky gut supplements. It is one of the most well-reviewed supplements for leaky gut. Consequently, it merits attention for leaky gut.

ActivatedYou Morning Complete


ActivatedYou Morning Complete is a daily wellness beverage including prebiotics, probiotics, and super greens foods. Morning Complete is, in reality, less of a leaky gut supplement and more of digestive aid. Prebiotics and probiotics promote a healthy microbiome, decreasing the inflammation that causes your symptoms. Some of the fruit and superfood greens do help in cellular activity. Therefore, it is entirely feasible that Morning Complete can assist in the elimination of leaky gut. However, we believe Morning complete is more of a digestive health supplement than a leaky gut vitamin.

Microbiome Plus Gastrointestinal


Microbiome Plus+ Gastrointestinal probiotics is a more comprehensive dietary supplement for gastrointestinal health that contains the probiotic L. reuteri, which acts to maintain the balance of beneficial bacteria in the gut and support proper digestive function.

In addition to promoting digestive health, the probiotic in Microbiome Plus+ Gastrointestinal has been found to support appropriate inflammatory responses. According to consumer evaluations and testimonies, the brand is credited with alleviating digestive problems. If you were searching for diet solutions, weight loss was not mentioned in the testimonials and is not pushed as a weight reduction solution.

Herbal Supplements for Leaky Gut

You can use additional supplements to restore your gut health besides probiotics. Additionally, you may want to try taking any of the vitamins listed below to aid in your recovery from a leaky gut.

Digestive Enzymes

These plant-based or microbiome supplements aid in the breakdown, absorption, and use of macronutrients to help a leaky gut. When taken with nutrient-dense meals, these leaky gut supplements work with your body’s limited supply of enzymes to promote complete digestion and support intestine repair mechanisms.

Marshmallow Root

This vitamin is multifunctional and can assist with stomach difficulties. A high mucilage indicates that it is a soluble fiber that swells and becomes more viscous when exposed to water. Establishing a protective barrier on the digestive tract lowers inflammation of the gut lining (which affects intestinal permeability), cures ulcers, and relieves diarrhea and constipation.

Slippery Elm

In the United States, slippery elm has been used for a long time as an effective gut healer and to promote a healthy gut. This supplement for leaky gut contains mucilage and stimulates nerve endings in the intestinal system to enhance natural mucus discharge, a key component of your gut lining. Additionally, it helps prevent ulcers and excessive acidity. In addition, it is rich in antioxidants, which can alleviate symptoms of inflammatory bowel disease.


This leaky gut supplement is excellent for healing intestinal harm and helping regenerate and rebuild the gut lining. It also reverses the damage caused by a leaky gut since it contains an amino acid that is essential for the health of the digestive and immune systems. Additionally, it reduces sugar cravings, which helps you maintain a healthy diet.

Lifestyle Changes Required For Treating Leaky Gut

In addition to taking a daily probiotic or a particular leaky gut supplement, several lifestyle changes can aid in the process of healing from the leaky gut like:

Clean Up Your Diet

If you enjoy processed meals, sugary drinks, and other foods such as gluten and dairy, you will benefit from eliminating or drastically lowering your consumption of these foods. These foods are some of the most prominent causes of leaky gut, and despite their delicious taste, they do little to protect the lining of your intestines. Additionally, regular alcohol consumption contributes to the deterioration of the intestinal lining, which affects the intestinal permeability level. If you abstain from such foods for a few months, you will notice a significant improvement in your gut health.

Improve Your Sleep

Every night, unstructured routines can hinder you from obtaining enough sleep. You should aim for seven hours of undisturbed sleep to give your body the time to recoup from the day’s activities. Without this time for your body to properly recover, you will likely experience diminished immune function, increased susceptibility to disease, and even deteriorating heart health. In addition, when you don’t sleep well, you tend to seek out meals that are not conducive to curing a leaky gut. Never compromise on your sleep.

Exercise More

Cardiovascular activity is related to the diversity of your gut microorganisms. Thus, boosting cardiac exercise directly affects your digestive system, enhancing its general function. In addition, exercise increases blood flow, which carries oxygen throughout the body, a further health benefit.

Manage Your Stress Better

Stress is related to numerous changes in your natural processes, including your eating preferences. When you’re under pressure and depression has a chance to set in, you’re more likely to make eating choices that influence the bacteria in your gut, altering the composition of your gut flora. Incorporate mind-body practices such as yoga, breathing exercises, and meditation to bring serenity and relaxation into your day and prevent cortisol from driving your hunger.

Dosage Guide For Leaky Gut Supplements

When it comes to the dosage of gut health supplements, it is of the utmost importance that customers follow the product’s specific instructions. Insufficient dosage may render it useless, while excessive dosage can overload the digestive system and produce severe effects.

Certain substances require a specific dose to be effective. For instance, each serving of L-glutamine should contain between 500 mg and 1,500 mg. However, this baseline has not been investigated as entirely as it should have been. Thus the amount required can vary.

Even though these probiotic-rich products emphasize the number of colony-forming units (CFUs), more significant numbers do not indicate a superior product. Quality is paramount, along with the way the product delivers its ingredients. This quality level is more essential than a precise CFU number.

Since the supplement’s components can vary greatly, buyers should always conduct research before selecting a treatment.

Side Effects of Leaky Gut Supplements

In no major study have dietary supplements with leaky gut been associated with significant adverse effects when taken at regular doses by healthy adults. Almost every supplement comes with some kind of potential adverse effects. Customers who have taken dietary supplements for leaky gut have discovered the following associated adverse effects after scouring several resources:

  • Diarrhea
  • Constipation
  • Bloating
  • Exhaustion
  • Headaches

And more!

These minor effects are considered natural and standard because the body must adjust to foreign substances. Supplements for leaky gut should be discontinued if patients have severe health consequences. If a person wants to use supplements to promote gut health, they must first consult a health care professional to decide if doing so is suitable.

FAQs About Leaky Gut And Supplementation

Q: Do leaky gut supplements do the trick?

A: Different dietary supplements for leaky gut function in various ways. Most contain prebiotics, probiotics, natural extracts, and other substances. Some purify the body with antioxidants to reduce intestinal inflammation, while others benefit the gut microbiota.

Q: What naturally repairs a leaky gut?

A: Although there is no specific treatment, one of the most effective treatments is lowering inflammation in the digestive system with a good diet, nutrients, and lifestyle modifications.

Q: What are the common indicators of Leaky Gut Syndrome?

A: Leaky Gut Syndrome can manifest in numerous ways. Constipation, diarrhea, and weight loss are some of the most prevalent symptoms of IBS. It can display differently in various patients.

Q: How is Leaky Gut Syndrome treated?

A: If a skilled chiropractor in Functional Medicine has diagnosed a patient with this syndrome using various stool and blood testing techniques, the next step is to address dietary and nutritional adjustments. It may be necessary to eliminate specific food sensitivities and add a supportive diet to help patients improve their intestines’ overall health.

Q: How does intestinal permeability affect health?

A: If the cheesecloth is torn, more clusters of the pearl necklace can escape. When that happens, your body does not recognize them and responds accordingly. This is how one becomes sensitive. You produce antibodies in response to these amino acid peptides. Your body will target any tissue or organ with the same amino acid sequence.

Q: What foods should those with leaky gut syndrome avoid?

A: Gluten is the leading offender. Gluten-free diets are frequently the first step in repairing a leaky gut. Other inflammatory foods such as dairy, wheat, pseudo-grains, nightshades, and eggs, as well as poisonous foods such as sugar, alcohol, and GMOs, have a significant role in developing symptoms.

Q: How can I tell if my leaky stomach has been repaired?

A: Once you’ve followed a routine to repair your gut, your symptoms (or lack thereof!) are the best indicator of your gut’s health. You may observe the disappearance of stomach difficulties, food sensitivities, skin issues, and improved autoimmunity results.

Q: What do you think about fermented foods? Are they healthy?

A: Fermented foods contain probiotics naturally. However, you must ensure that no chemicals, sugar, or salt have been added to the meal. Probiotic-rich foods include sauerkraut, kimchi, and even kefir or plain, whole yogurt. The latter two are dairy-based and must be avoided for the time being while beginning to treat leaky gut.

Q: Can leaky gut induce acid reflux?

A: Acid reflux is not always caused by excessive stomach acid. In reality, it frequently develops as a result of low acid. When you have low acid, i.e., a more alkaline kind, you not only have an accumulation of undigested food, but you can also get reflux, which is believed to be the result of fermentation rather than the breakdown of food. This can also manifest as bloating and general “gassiness,” and frequently does so before reflux.

The Top Leaky Gut Supplements in 2022 Conclusive Remarks

Gut microbiomes are unstable areas, and your gut microbiome could be affected the moment they start to appear. A leaky gut syndrome is one of the worst digestive system disorders, and it is not a pleasant disease to have. It is not so surprising that many of us have leaky guts due to unhealthy and fast-food-style diets and regular antibiotic use. Our habits and diets have eroded the lining of our intestines, resulting in severe and potentially fatal intestinal problems. The good news is that herbal leaky gut supplements can help these digestive issues.

The best leaky gut supplements of the present day contain components that have been shown to improve gut health in various ways. A lot of new research suggests that supplements may be able to alleviate this inflammation and halt the negative impacts of a leaky gut syndrome. Most leaky gut supplements contain prebiotics, natural extracts, and other herbal components. Some purify the body with antioxidants to reduce intestinal inflammation, while others support the gut flora.

Even though a decent supplement can benefit the stomach, other daily lifestyle choices favor the body. Most physicians concur that a diet excludes processed foods, alcohol, and tobacco is an excellent first step. Incorporating more fruits and vegetables into the diet will considerably improve digestion, thereby making the whole food digestive process much simpler on the intestines.

Even though there is still much to understand about the causes and treatment of a leaky gut, choosing better food and lifestyle choices is a step in the right way. If you’re looking for a noninvasive method to improve your gut health, we recommend that you consider the top leaky gut supplements above and take the next step toward a better life.


The news and editorial staff of Sound Publishing, Inc. had no role in the preparation of this post. The views and opinions expressed in this sponsored post are those of the advertiser and do not reflect those of Sound Publishing, Inc.

Sound Publishing, Inc. does not accept liability for any loss or damages caused by the use of any products, nor do we endorse any products posted in our Marketplace.